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Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.

        Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein tha

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Book ID Asin: B004JHYRPE
Book Title: Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer
Book Author: Robert Bazell
Book Format: unknownBook Price: unknown
Book Category: Kindle Store, Kindle eBooks, Health, Fitness & Dieting and unknown
Book Rating: 119 ratings

Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer by Robert Bazell Book Review

Name: Steven F. Wolfe
Rating: 5.0 out of 5 stars
Title: Fascinating and detailed.
Date: Reviewed in the United States on August 31, 2018
Review: A compelling read about the discovery of the drug Herceptin. My education crossed paths with both Dr. Dennis Salmon and Dr. John Glaspy during my internship at UCLA in 1992. Both of them were my attending physicians during my internship. In fact, my first rotation out of medical school (from UCSF) was on the solid oncology unit at UCLA and a few short months later it was on the bone marrow transplant unit. I encountered many deathly sick patients and sadly many died. I wish I knew what Dr. Slamon and Dr. Glaspy were doing at the very time of my internship to help save the lives of their patients. They are to be commended for advancing the treatments for breast cancer. All these years later I wish that my internship had started with one of the oncology attendings telling me this: "Your internship is going to suck. You will take care of devastatingly sick patients many of whom will die. You will be fatigued and get little sleep. You will become attached to them and feel the pain that they and their families go through. And often, it will be hopeless, but we want you to know that as you are on the wards taking care of them we are working on the advances that one day will help to save their lives. If I had only known about those first patients ever to receive HERCEPTIN it might have changed not only my year of internship but all the years since. I recognize that it is in the 26 years since doing my internship that many new treatments have in fact come along to save or at least add years to people's lives. It was 9 years after my internship that the drug GLEEVEC was approved--I wish it had been available to save the life of one of my patients, JK. I watched as the attendings and fellows and residents and myself were completely helpless in saving him. Robert Bazell is to be commended for not only reporting the science, but the politics and bureaucracy of bringing a life saving drug to market.

Name: Marily
Rating: 5.0 out of 5 stars
Title: Amazing Miracle, Thank you Dr Slamon!
Date: Reviewed in the United States on November 3, 2016
Review: Reading this book, and yes I saw the movie...again pointed out, How Very BLESSED I am to be alive! If Dr Slamon had given up on his fight to bring Herceptin to fruition...I and a very large number of women would have been dead years ago! I was able to really experience all the problems and difficulties he and many others faced. Reading about those who fought hard for its inception increases my respect and admiration. If not for those who worked so diligently to bring these developments to life many would be dead. In 1999 I was diagnosed with this aggressive form of Cancer. I truly appreciate all those women who went before me. After 8 years on Herceptin, with an OK from Dr Slamon, My weekly Herceptin was discontinued. I have been Blessed now with 16 years of life, when I had originally been given a few months.

Name: Human-At-Large
Rating: 5.0 out of 5 stars
Title: VERY Interesting
Date: Reviewed in the United States on September 27, 2021
Review: I was fascinated by this book. I don't think a person has to have cancer and be HER2+ to find this book very interesting. Learning the process and inner workings of Genentech was fascinating to me. And, as person who does have cancer and is HER2+, I am ever-so-greatful the scientists won out over the politics and money. Additionally, the book is really well written, and I, an academic type, couldn't put it down.

Name: Top Cat
Rating: 4.0 out of 5 stars
Title: Good, but dated.
Date: Reviewed in the United States on December 23, 2014
Review: Very interesting to read since I am now using this miracle drug for a recent diagnosis. I was surprised to see it was published so long ago (1998) and I'd love it to be updated. The personal stories of the women who fought for this drug, and those who didn't get to benefit from it, are the most compelling. I am so grateful to benefit from all the pioneering work that's been done. So why does this still cost $10,000.00 for each infusion 16 years later? I'm getting it for a year, maybe $180,000.00, nearly all covered by insurance. An update on the costs of developing, marketing, and distributing the drug would be helpful.

Name: myriam palmer
Rating: 5.0 out of 5 stars
Title: History of discovery of Her-2 and Herceptin
Date: Reviewed in the United States on August 4, 2017
Review: Terrific book about discovery of Her-2 and Herceptin. Although published in 1998, it gives the back story of these discoveries and the journey to FDA approval. Very informative and inspirational. As a breast cancer patient, I am grateful for everyone who participated in the development of the drug and the women who participated in the trials that resulted in widespread availability for women who are Her-2 positive.

Name: Kindle Customer
Rating: 5.0 out of 5 stars
Title: Discovery of Herceptin
Date: Reviewed in the United States on February 4, 2022
Review: A book about one of the greatest discovery in oncology,Trastuzumab ,commercial name Herceptin, wich saved since then so many her2 positive women.It opened the way for more treatments but this one was revolutionary.
The book is not complicated with scientific terms,it's more like a captivating fiction.
Easy to read and helpful for those who have this desease.

Name: Antonette L. Buffo
Rating: 5.0 out of 5 stars
Title: fabulous!!
Date: Reviewed in the United States on September 4, 2014
Review: I am a breast cancer patient currently winding down on my treatment of Herceptin....4 more to go!!! I had 4 rounds of AC then 12 rounds of Taxol and Herceptin with 3 rounds of a cousin to Herceptin which I think was prujeta??. Then a bilateral with no des ease evident and no lymph nodes affected. Then 9 months of Herceptin only....this is the treatment for HER2 nue positive in 2013/2014.

Name: Avadeeee
Rating: 5.0 out of 5 stars
Title: Recommend
Date: Reviewed in the United States on March 23, 2020
Review: Good read