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Is there a right way to study how the brain works? Following the empiricist's tradition, the most common approach involves the study of neural reactions to stimuli presented by an experimenter. This 'outside-in' method fueled a generation of brain research and now must confront hidden assumptions about causation and concepts that may not hold neatly for systems that act and react.György Buzsáki's The Brain from Inside Out examines why the outside-in framework for understanding brain function has become stagnant and points to new directions for understanding neural function. Building upon the su

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Book ID Asin: B07QMY6MQ9
Book Title: The Brain from Inside Out
Book Author: PhD Buzsáki György MD
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Book Category: Books, Medical Books, Medicine and unknown
Book Rating: 124 ratings

The Brain from Inside Out by PhD Buzsáki György MD Book Review

Name: BlackBox Explorer
Rating: 5.0 out of 5 stars
Title: Amustreadforallwhoexplorethebrain
Date: Reviewed in the United States on May 27, 2019
Review: This is one of the best Neuroscience books of all time, written by a true genius/polymath of our time, who is just a walking encyclopedia of scientific knowledge. This is a must-read for all who wish to understand how the brain works - from aspiring students to seasoned experts, and interested lay public to forward-thinking funding agencies.Dr. Buzsáki presents a profound and critical re-assessment of systems level Neuroscience research today, calling for a paradigm shift from the prevailing “outside-in” perspective (i.e., characterizing neuronal functions by externally delivered stimuli or preconceived psychological notions) to an alternative “inside-out” framework (centered on internally generated network oscillations).The author flips the traditional view of perception-action cycle around and argues that it is the action that grounds all incoming perceptual inputs, that it is the active exploration of environment that provides meaning to the neural information being processed.The early chapters lay out the foundation of this paradigm-shifting argument, amply supported by a comprehensive review of much of Systems Neuroscience, especially the notion of corollary discharge from motor/frontal cortex to sensory/association cortex. This idea is prescient, as recent data from cortex-wide and brain-wide large-scale neural recordings have shown that this action-centered grounding may very well be correct.The middle chapters lead readers on a deep dive into the world of brain rhythms, the hippocampal place cell system, the logic and mechanisms of gain control in neural network operation. They are filled with gems of knowledge, complete with detailed footnotes on various subtle aspects and entertaining anecdotes. Reading through the chapters, I’ve gained an integrated understanding of all these various pieces of information that I’ve encountered over the years. It is as if having conversed with a wise sage, which I imagine Dr. Buzsáki must be.In the final chapters, Dr. Buzsáki presents new ideas on the log-normal distributions found in all aspects of neuronal organization and how they support a new unified theory of fast and slow dynamics in the brain. He also lays out a radical new idea that the “inside-out” perspective suggests that learning is not an internalized representation of experiences but a matching process between the internally generated neural network patterns and environmental stimuli - an inborn dictionary of words devoid of meaning that is matched with their meanings through an individual’s exploration of its environment in each unique lifetime.Overall, the book is profound and full of both wisdom for both science and beyond. It challenges one’s notion of how the brain and the world work, and it inspires new ideas for discussion and experiments. This is a book that should be read by all, for both comprehensive scientific knowledge and deep intellectual reward.

Name: Howard Goldowsky
Rating: 5.0 out of 5 stars
Title: Howphysicalmatterinthebrainmakesthemagichappen
Date: Reviewed in the United States on August 5, 2019
Review: Gyorgy Buzsaki's new book, "The Brain from Inside Out," teaches us non-neuroscientists how physical matter in the brain makes the magic happen. The ideas are covered at an undergraduate level.According to the inside-out approach, all training in the brain is built on pre-existing oscillations and dynamics, which are present at birth. These pre-existing dynamics support Chomsky's and others claims that the brain is pre-wired for language and other skills. Buzsaki's hypothesis is that pre-existing brain structure at birth affords an action-perception cycle precipitated by action. This model disputes the existing but more intuitive hypothesis of a perception-action cycle precipitated by perception. Throughout the text, Buzsaki provides example after example from many experiments (from his own lab and others), that support his action-perception model. Everything humans are good at can be thought about as an action-perception cycle, from language to planning.During the action-perception cycle the brain acts, predicts, and then compares its predictions to perceptions. Ten levels of brain oscillations, from 1/40 Hz to 600 Hz, "train" self-organization of cell assemblies that build neural syntax. This neural syntax builds representations as proxies for space and time, even concepts. Throughout the narrative, we learn why most signals in the brain are based on logarithmic scales, why the brain's network structure is the way that it is, what a "corollary discharge" is (essentially a signal that the brain sends to its sensors to tell them to stop working!), and many other fascinating pieces of neuroscience.The book is easily accessible, requiring only a high school level of mathematics. Scores of diagrams and plots highlight experiments and concepts. The writing is clear and passionate. In various places Buzsaki takes a tangent or two into personal stories about his career or how he was motivated by his early mentors and professors. At one point he tells an amusing story about how, for a long stretch of time, he remained ignorant of Khaneman's famous cognitive bias results, and how this ignorance led to an embarrassing event. Fun stuff.Buzsaki also shows how the two most important recent discoveries from neuroscience, place cells and grid cells, fit into his inside-out paradigm. While the book does not cover every recent discovery in neuroscience, this book along with Buzsaki's earlier "Rhythms of the Brain" can cover plenty of ground. His books provide the level of breadth, technical detail, and inspiration needed to satisfy general curiosity or an ascent into brain-inspired research.