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Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence.

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Book ID Asin: B003UYUP58
Book Title: The Emperor of All Maladies: A Biography of Cancer
Book Author: Siddhartha Mukherjee
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Book Format Name: Audiobook
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Book Format Name: Hardcover
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Book Format Name: Paperback
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Book Rating: 5,287 ratings

The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee Book Review

Name: Book Shark
Rating: 5.0 out of 5 stars
Title: A Literary Achievement of Science
Date: Reviewed in the United States on January 1, 2013
Review: The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee

"The Emperor of All Maladies" is a literary achievement of science. It's an enlightening journey through the history of cancer through the eyes of a coming-of-age oncologist. A beautifully written book that treats this complex topic of cancer with the utmost care and respect while providing the reader valuable insights into the scientific quest to eradicate or control this insidious disease. This outstanding 608-page book is broken out into six major parts: 1. "Of blacke cholor, without boyling", 2. An Impatient War, 3. "Will you turn me out if I can't get better?", 4. Prevention is the Cure, 5. "A Distorted Version of our Normal Selves", and 6. The Fruits of Long Endeavors.

Positives:
1. Outstanding accomplishment of literary science. Extensive research of cancer and conveyed to the masses in an enlightening readable fashion. Kudos!
2. Engaging and humane prose.
3. What sets this book apart is the author's ability to interweave human stories into the biography of cancer thus achieving a perfect balance of humanity and science.
4. Great facts and fascinating scientific tidbits about cancer throughout this book.
5. Cancer...what it is, and the never ending scientific quest to eradicate or control it.
6. Cancer has many manifestations. This book covers many of them through the eyes of the patients, scientists and doctors. Leukemia and breast cancer, do get special attention.
7. Innate ability of Dr. Mukherjee to provide details with panache.
8. The history of the drugs developed to combat the many manifestations of cancer. The history of the agencies, and support groups. The scientists behind the design, development and deployment of the drugs.
9. Great quotes, "Cancer thus exploits the fundamental logic of evolution unlike any other illness. If we, as a species, are the ultimate product of Darwinian selection, then so, too, is this incredible disease that lurks inside us".
10. A look into the history of ancient diseases. The progression (not always in a straight line either) of science as it relates to treating diseases. The key discoveries that were instrumental to progress, anesthesia as an example. The discovery of radium in 1902.
11. The history of organizations launched to fund research. Special mention to the tireless efforts of Mary Woodard Lasker and Sidney Farber.
12. Conducting clinical research. The trials and tribulations. The various treatments and effects. A lot of focus on chemotherapy. The multidrug concoctions. The reality of the results. The tamoxifen trial.
13. The causes of cancer. The various theories. As an example a look into the somatic mutation hypothesis of cancer.
14. The quest to understand the biological behavior of cancer before going on an all out attack. Fascinating stuff.
15. The quest to prevent diseases. Many examples of historical cases: the "chimney-sweepers' cancer, tobacco, malaria, to name a few. Find out the extreme experiment that put one scientist's own life at risk.
16. The history behind screening trials. Pap smears, mammography, the findings, and the lessons learned.
17. The insidious disease...AIDS. Retroviruses.
18. The link between chromosomal changes and cancer. The causes.
19. Proto-oncogenes. "Cancer was intrinsically loaded in our genome, awaiting activation". The first cogent and comprehensive theory of carcinogenesis.
20. Understanding the progression of cancer. "Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves."
21. The six rules that explain core behavior of more than a hundred types of tumors.
22. The three new Achilles' heels of cancer. The three essential ingredients for a targeted therapy for cancer.
23. The current biological and societal challenges of cancer. The pathway disease.
24. Excellent links to notes.
25. The inclusion of a glossary and bibliography.

Negatives:
1. At over 600 pages, it does require an investment in time. Thankfully, it's time well invested.
2. Lack of charts and illustrations would have added value. Could have been added to appendices to avoid disrupting elegant prose.
3. It can be an emotional read sometimes as the reader will find themselves invested in the lives of so many people...let's face it, we are talking about dealing with cancer.
4. Some readers will get lost among the many and recurring storylines.
5. The photographs would have added more value if they would have been inserted in the context of the narrative instead of a separate appendix.

In summary, this is an outstanding and important book. What sets this book apart is Dr. Mukherjee's ability to weave multiple storylines into a fascinating narrative about the history of cancer with just the right touch of humanity. This was an ambitious book and I can only imagine how daunting a quest this was but the author succeeds and as a result we the readers benefit from the knowledge and wisdom. I can't recommend it enough!

Further suggestions: "

Name: prisrob
Rating: 5.0 out of 5 stars
Title: The Burden, The Mass, Onkos
Date: Reviewed in the United States on November 13, 2010
Review: **I am pleased that Dr. Mukherjee has won the Pulitzer prize in general non fiction for this book, 4-18-11

In the United States one in three women and one in two men will develop cancer in their lifetime. Dr Siddhartha Mukherjee, a medical oncologist, has written a definitive history of cancer. It may be one of the best medical books I have read. Complex but simple in terms of understanding. A timeline of a disease and those who waged the wars. In 1600 BC the first case of probable breast cancer was documented. In the thousands of years since, the Greek word, 'onkos', meaning mass or burden, has become the disease of our time. Cancer. The title of the book, is "a quote from a 19Th century physician" Dr Mukherjee had found inscribed in a library book that "cancer is the emperor of all maladies, the king of our terrors".

As a health care professional and as a woman who is six years post breast cancer, Cancer has played a big part in my life. I used to walk by the Oncology clinic, and quicken my pace. I used to give chemotherapy to my patients, before it was discovered that the chemo was so toxic that it needed to be made under sterile conditions and given by professionals who specialized in Oncology. Dr Mukherjee, wisely discusses cancer in the context of patients, those of us who suffer. After all it is because of the patients, the people who have gone before us, who have contracted some form of cancer, they are the base of this science.

Dr Mukherjee started his immersion in cancer medicine at the Dana Farber Cancer Institute in Boston. He relates the beginning of the study of ALL, Acute Lymphocytic Leukemia, by Dr Sidney Farber in 1947. Dr Farber, a pathologist at the time decided to change his focus and start caring for patients. He was given a medication to trial for ALL, and though most of his patients died, some survived to remission. This opened his world and with the help of Mary Lasker, and Charles E Dana, philanthropists, they opened one of the first clinics that specialized in cancer care and research, The Dana Farber Cancer Center. Dr Mukherjee gives us the timeline of ALL and lymphomas and the medications that turned into chemotherapy. The development of specific care for blood cancers and the emergence of AIDS and patient activism. He discusses the surgery for breast cancer. It was thought that the more radical the surgery the better the outcomes. We now know that lumpectomies have an excellent outcome. But, women before me had a radical removal of breast, chest tissue, lymph nodes and sometimes ribs. The lesson learned is that breast cancer is very curable now and all those men and women, the patients who suffered, gave us the answers and cancer care has moved on.

The onslaught of chemotherapies changed the face of cancer, and the 1970's served us well. In 1986 the first outcomes of cancer care were measured. Tobacco emerged as an addiction and soon lung cancer was a leading cause of death. Presidential Commissions ensued, politics entered the world of cancer, the war against cancer and the war against smoking. The Pap smear was developed, and prevention came to the fore. The two sides of cancer, the researchers and the physicians at the bedside, who often thought never the twain shall meet, recognized the importance of research to bedside.

The story of the boy 'Jimmy' from New Sweden, Maine, became the face of childhood cancer. The Jimmy Fund, a Boston Red Sox charity in Boston, is still going strong today. 'Jimmy' opened the door to the public for the need for money and research, and care for those with cancer. We follow Dr Mukherjee with one of his first patients, Carla, from her diagnosis through her treatment. He has given a face to cancer. We all know someone with cancer, those who survived and those who did not. Cancer prevention is now the wave of the future.

"Cancer is and may always be part of the burden we carry with us," says Dr Mukherjee. He has now written a "biography of cancer" for us, those without special medical knowledge. However, he does go astray in some discussions such as genetics. I have an excellent medical background, and found I was floundering at times. As I discovered,and Dr. Mukherjee agrees, our patients are our heroes. They/we withstand the horrors of cancer, and the horrific, sometimes deadly treatments. The stories of his patients make us weep, and the complex decision making about their care make him the most caring of physicians.

The 'quest for the cure' is the basis of all science and research, and Dr Mukherjee has written a superb tome in language that we can all attempt to understand. The biography of Cancer. Cancer may always be with us,Dr Mukherjee hopes that we outwit this devil and survive.

Highly Recommended. prisrob 11-13-10