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From Animal Testing to Organ-on-Chip: How Technology is Changing Drug Development

Amayra Shah2023/05/01 09:53

The Organ on Chip Market was estimated at US$ 111 million in 2021 and is expected to grow at a CAGR of 28.43% during 2022-2028 to reach US$ 647.6 million in 2028.

Organ on Chip Market report provides detailed insights into the market dynamics to enable informed business decision making and growth strategy formulation based on the opportunities present in the market. Organ-on-chip (OOC) technology is an emerging area of research that is transforming the drug development process. OOC devices are micro-engineered systems that mimic the structure and function of human organs. They offer a more accurate and reliable alternative to animal testing, allowing scientists to test the safety and efficacy of new drugs before they are tested on humans

The organ on chip market was estimated at US$ 111 million in 2021 and is expected to grow at a CAGR of 28.43% during 2022-2028 to reach US$ 647.6 million in 2028. Organs-on-chips (OOCs) are miniature plastic gadgets with biocompatible microfluidic chambers that house numerous living human cells in a 3D culture to mimic various physiological functions of body organs. A promising substitute for animal models are organs-on-chips that replicate the physiology of human organs at the cellular level.

One of the main drivers of the organ-on-chip market is the need for more accurate and reliable drug testing methods. Traditional drug testing methods rely on animal models, which can be expensive, time-consuming, and often fail to accurately predict the human response. OOC devices offer a more realistic and reliable alternative, as they can reproduce the complex physiological and biochemical interactions of human organs.

Another factor driving the growth of the organ-on-chip market is the increasing focus on personalized medicine. OOC devices can be customized to mimic the specific disease conditions of individual patients, allowing for more targeted drug development and treatment. This has the potential to revolutionize the healthcare industry, as it could lead to more effective treatments and better patient outcomes.

The organ-on-chip market is also benefiting from advances in microfabrication and microfluidics technologies. These technologies allow for the precise control and manipulation of fluids and cells within OOC devices, enabling researchers to create highly accurate and reproducible models of human organs.

The market is divided based on offering, organ, application, and end user. On the basis of offering, the market is segmented into devices, testing services.

On the basis of organ, the market is divided into lung-on-chip, heart-on-chip, liver-on-chip, intestine-on-chip, kidney-on-chip, skin-on-chip, blood-brain-barrier-on-chip, others. Due to fewer lung transplants, which has prompted the development of laboratory-engineered chips to mimic their functions and for drug screening for respiratory disorders, the lung-on-chip segment of the organ-on-chip market has dominated the market since 2021 and is predicted to continue dominating during the forecast period.

On the basis of application, the market is further segmented into toxicology research, drug discovery, molecular biology, disease modelling, food safety and others.

The organ on chip market is broken down geographically into areas like North America, Europe, Asia-Pacific, and the Rest of the World (RoW). In 2021, North America held the largest share of the worldwide organ-on-chip market, and it is expected to hold this position throughout the forecast period. This is attributable to a growth in the use of technologically advanced models, the presence of important players, and an increase in research and development operations for the development of new drugs. However, because to an increase in R&D efforts, an increase in healthcare spending, and diverse tactics among key competitors, the Asia-Pacific region is predicted to have a significant organ-on-chip market opportunity. In addition, according to the prediction for the Asia-Pacific organ-on-chip market, India and China would expand at rapid CAGRs.

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However, there are still some challenges that need to be addressed before OOC devices can become widely adopted. One of the main challenges is the high cost of development and production. OOC devices are still in the early stages of development, and the technology is not yet widely available. This makes it difficult for small companies and academic institutions to access the technology and develop their own OOC devices.

Another challenge is the complexity of the technology. OOC devices require expertise in multiple fields, including microfabrication, microfluidics, and biology. This can make it difficult for researchers to design, develop, and use the devices effectively.

Despite these challenges, the organ-on-chip market is expected to grow rapidly in the coming years, driven by the increasing demand for more accurate and reliable drug testing methods. As the technology continues to advance and become more accessible, it has the potential to transform the drug development process and revolutionize the healthcare industry.



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