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Which painkiller is best for long term use: Non-opioid pain relievers like acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are often preferred for long-term pain management due to a lower risk of dependence and side effects compared to opioids. However, the choice depends on the specific pain condition and should be discussed with a healthcare provider.

Does tramadol increase serotonin? Yes, tramadol can increase serotonin levels in the brain. It not only acts on opioid receptors but also inhibits the reuptake of serotonin, a neurotransmitter associated with mood regulation. This dual mechanism contributes to its pain-relieving effects but also increases the risk of serotonin syndrome when taken with other drugs that affect serotonin.
Which painkiller is best for long term use: Non-opioid pain relievers like acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are often preferred for long-term pain management due to a lower risk of dependence and side effects compared to opioids. However, the choice depends on the specific pain condition and should be discussed with a healthcare provider.

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