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A synthetic opioid analgesic specifically designed to relieve moderate to severe pain is called tramadol. It is offered for sale under a number of brand names, including as Citra, Ultram, and Ultracet. Tramadol blocks the reuptake of the neurotransmitters norepinephrine and serotonin by attaching to mu-opioid receptors in the central nervous system.

Acute and chronic pain are two of the many forms of pain for which tramadol is prescribed. It is frequently used to treat diseases including osteoarthritis and fibromyalgia, as well as pain following surgery or accident.

Usually, immediate-release or extended-release pills containing tramadol are taken orally. The dosage is determined by the patient's response and the degree of pain.