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In Summary

Commonly reported side consequences of ivermectin include: fever, pruritus, and skin rash. See beneath for a complete listing of detrimental effects.

For the Consumer

Applies to ivermectin: oral pill

Side results requiring on the spot clinical interest

Along with its needed consequences, ivermectin can also cause a few unwanted consequences. Although now not all of those side outcomes may arise, in the event that they do arise they'll want clinical attention.

Check together with your physician as quickly as possible if any of the subsequent aspect consequences arise even as taking ivermectin:

Less not unusual—for the treatment of river blindness (onchocerciasis) handiest

Eye or eyelid irritation, ache, redness, or swelling

Side effects not requiring on the spot scientific attention

Some facet consequences of ivermectin may additionally arise that generally do no longer need medical interest. These aspect outcomes may match away for the duration of remedy as your frame adjusts to the medicine. Also, your health care expert may be in a position to tell you about ways to prevent or reduce some of those side effects.

Check along with your health care professional if any of the following facet outcomes maintain or are bothersome or when you have any questions about them:

More commonplace—for the remedy of river blindness (onchocerciasis) handiest

Fever, itching or skin rash

joint or muscle ache

painful and tender glands in neck, armpits, or groin

rapid heartbeat

Less commonplace—for the treatment of river blindness (onchocerciasis) only

Headache

swelling of the face, fingers, palms, feet, or legs

Less not unusual—for the treatment of strongyloidiasis best

Diarrhea

dizziness

skin rash or itching

Rare—for the treatment of river blindness (onchocerciasis) only

Lightheadedness whilst getting up from a mendacity or sitting position

Rare—for the treatment of strongyloidiasis only

Loss of appetite

shaking or trembling

sleepiness

For Healthcare Professionals

Applies to ivermectin: compounding powder, oral pill

General

Ivermectin is nicely tolerated in comparison to different microfilaricidal retailers (i.E., thiabendazole, diethylcarbamazine). Adverse reactions (i.E., pruritus, fever, rash, myalgia, headache) arise typically for the duration of the first three days after remedy and appear to be related to the volume of parasitic infection and systemic mobilization and killing of microfilariae. The majority of reactions can typically be treated with aspirin, acetaminophen and/or antihistamines. Adverse outcomes generally tend to occur with lesser frequency all through durations of retreatment.[Ref]

Ocular

Ocular side outcomes have included eyelid edema, anterior uveitis, blurred vision, conjunctivitis, limbitis, punctate opacity, keratitis, strange sensation within the eyes, and chorioretinitis/choroiditis; however, those effects are also related to the sickness onchocerciasis. Loss of vision has come about hardly ever however normally resolved without corticosteroid treatment. Conjunctival hemorrhage has been reported at some point of postmarketing enjoy in patients dealt with for onchocerciasis.[Ref]

Other

Worsening of Mazzotti reactions, such as arthralgia, synovitis, lymph node enlargement and tenderness, pruritus, skin involvement (inclusive of edema, papular and pustular or frank urticarial rash), and fever, has been stated during the first four days following remedy for onchocerciasis.

Nervous gadget

Nervous gadget facet results have blanketed dizziness, headache, somnolence, vertigo, and tremor. Serious or deadly encephalopathy has been pronounced rarely in sufferers with onchocerciasis, and heavily infected with Loa loa, both spontaneously or after remedy with ivermectin. Seizures had been mentioned all through postmarketing experience.[Ref]

Gastrointestinal

Gastrointestinal aspect effects have protected anorexia, constipation, diarrhea, nausea, vomiting, and belly distention.[Ref]

Other

Other facet results have protected asthenia, fatigue, abdominal ache, chest soreness, facial edema, and peripheral edema.

Hematologic

Hematologic side results have blanketed decreased leukocyte matter (three%), eosinophilia (3%), and improved hemoglobin (1%). Hematomatous swellings related to extended prothrombin times have been pronounced, but the scientific significance is unknown. Leukopenia and anemia have been said in as a minimum one patient.[Ref]

Hepatic

Hepatic aspect outcomes have covered accelerated ALT and/or AST. Elevated liver enzymes, expanded bilirubin, and hepatitis have been pronounced throughout postmarketing enjoy.[Ref]

Cardiovascular

Cardiovascular aspect results have included tachycardia and orthostatic hypotension. EKG adjustments, inclusive of extended PR c programming language, flattened T waves and peaked T waves, have been suggested in unmarried instances. Hypotension (usually orthostatic hypotension) has been suggested at some point of postmarketing enjoy.[Ref]

Dermatologic

Dermatologic side consequences have protected pruritus, rash, and urticaria. Toxic epidermal necrolysis and Stevens-Johnson syndrome were reported all through postmarketing experience.

Respiratory

Respiratory aspect consequences have covered worsening bronchial bronchial asthma, laryngeal edema, and dyspnea.[Ref]

Musculoskeletal

Musculoskeletal aspect effects have blanketed myalgia.

Renal

Renal facet outcomes have blanketed uncommon transient proteinuria.

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