Staudinger Ligation
Staudinger ligation is to capture the intermediate of azaylide with electrophilic groupsgenerally located on triaryl phosphines, and act in aqueous medium to obtain the intramolecular amido phosphine oxide after rearrangement. Introduction Staudinger ligation is a metal-free catalytic click reaction between organic azide and phosphine and it belongs to a bio-orthogonal reaction. It has the following three elements: the reaction must occur in aqueous solution, the catalyst or reactant involved in
